Familial Kidney & Bladder Diseases in Dogs

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Juvenile renal disease and other familial and congenital renal diseases are seen in more than thirty breeds of dogs. Twenty two of these breeds have a renal dysplasia which is similar to that seen in Standard Poodles. I have put an (RD) for renal dysplasia after their breed names. Even in breeds with the same type of JRD, such as renal dysplasia, the modes of inheritance can be different. Ages at onset of symptoms can vary from a few weeks (Cairn terriers) to 5 - 11 years (German Shepherds, Welsh Corgis, Beagles). Modes of inheritance can vary from X linked dominant (Samoyed) to autosomal recessive (Soft-Coated Wheaten Terrier, Cairn Terrier, Shih-Tzu), autosomal dominant (Bull Terrier), to unknown familial (most of the others).

bullet Affected Breeds
bullet Juvenile and Familial Renal Diseases in Dogs: Symptoms, Diagnosis, Treatment, Research, References
bullet Familial and Hereditary Renal Diseases in Breeds with Brief Description of Each
bullet Clinical article on Juvenile Renal Disease (JRD) in Standard Poodles
bullet Congenital Diseases of the Urinary Tract: renal aplasia, polycystic disease, familial juvenile renal disease, ectopic ureters, other congenital diseases : from WSU
bullet Familial Renal Disease in Lhasa Apsos
bullet Wedge Biopsy Study of 69 Lhasa Apsos Without Symptoms 75% Affected to Some Degree
bullet Renal Dysplasia in Shih Tzu
bullet Familial Nephropathy in English Cocker Spaniels
bullet Renal Dysplasia in Soft Coated Wheaten Terriers
bullet Juvenile Renal Dysplasia (JRD) in Norwegian Elkhounds
bullet Identifying Renal Disease in Soft Coated Wheaten Terriers
bullet Hereditary Kidney Disease in Lhasa Apsos & Shih-Tzus
bullet Shar-Pei Amyloidosis(Familial Shar-Pei Fever)
bullet Cystinuria in Newfoundland Dogs
bullet Fanconi Syndrome in Basenjis
bullet Fanconi Syndrome and Basenji Health
bullet Fanconi Disease Management Protocol for Veterinarians 2003
bullet Kidney Disease in Miniature Schnauzers
bullet Genetic Kidney Diseases of Bull Terriers
bullet Kidney Disorders in Dalmatians
bullet Urinary Stone Formation in Dalmatians and Other Dogs
bullet Dalmatian Stone Forming
bullet Urinary Stones: General Preventative Procedures
bullet Urinary Stones: Tabulation of Purine-Yielding Foods
bullet Dietary Management of Dogs With Urinary Stones
bullet Fifteen Years of Data On Almost 3,000 Dalmatian Stones
bullet Polycystic Renal Disease

The following breeds are some of those in which familial and other renal diseases are seen:

(some of the breeds in which juvenile and familial renal diseases are seen)

  • Airedale Terriers (RD)
  • Alaskan Malamutes (RD)
  • Basenjis (Fanconi-like syndrome)
  • Beagles (unilateral agenesis, dysplasia, & polycystic kidneys)
  • Bedlington Terriers (RD)
  • Boxers (RD)
  • Bulldogs (RD)
  • Bull Terriers (glomerulopathy)
  • Cairn Terriers (polycystic kidneys)
  • Cavalier King Charles Spaniels (RD)*
  • Chinese Shar-Pei (amyloidosis)
  • Chow Chows (RD)
  • Cocker Spaniels (glomerulopathy and RD)
  • Collies (glomerulopathy)
  • Doberman Pinschers (unilateral agenesis and glomerulopathy)
  • Flat-coated Retriever (RD)*
  • Golden Retrievers (RD)
  • Great Danes (RD)
  • Great Pyrenees (RD)
  • Irish Wolfhounds (RD)
  • Keeshonds (RD)
  • King Charles Spaniels (RD)
  • Lhasa Apso (RD)
  • Miniature Poodles (polycystic kidneys)
  • Miniature Schnauzers (RD and Fanconi-like syndrome)
  • Newfoundlands (glomerulopathy)
  • Norwegian Elkhounds (tubulointerstitial nephropathy and Fanconi-like syndrome
  • Old English Sheepdogs (RD)
  • Pekingese (unilateral agenesis and RD)
  • Samoyeds (glomerulopathy)
  • Shetland Sheepdogs (unilateral agenesis, medullary cystic disease and Fanconi-like syndrome)
  • Shih Tzus (RD)
  • Soft-Coated Wheaten Terriers (RD)
  • Standard Poodles (RD)
  • Swedish Foxhounds (RD)
  • Tibetan Spaniel (RD)
  • Tibetan Terrier (RD)
  • Welsh Corgis (telangiectasia)
  • Yorkshire Terriers (RD)

Reference: 1. Kruger, J.M., Osborne, C.A., et al. : Congenital and Hereditary Disorders of the Kidney. Veterinary Pediatrics Dogs & Cats from Birth to Six Months., 2nd edition. (J.D. Hoskins, ed.) W.B.Saunders, Philadelphia, Pa, 1995: pp 401-406.

* A sex predisposition for renal dysplasia was detected for Flat-coated Retrievers and Cavalier King Charles Spaniels, in which females represented 87,5% and 85,0 %, respectively, of the cases. (October 24, 2003) Renal dysplasi hos hund. http://vfak-epsilon.slu.se/archive/00000046/

I have also heard from a number of owners of Labrador Retriever puppies who have been diagnosed with a juvenile renal disease., and I have had reports of a familial renal dysplasia in English Setters.

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Last edit: March 10, 2005